Chlorogenic Acid: Bulk Buyers Guide to Benefits, Dosing Sourcing Premium Extracts

What is Chlorogenic Acid?

Chlorogenic Acid (CGA) is a potent polyphenol abundantly found in:

• Green coffee beans (primary source)
• Artichokes, strawberries, apples
• Eucommia ulmoides leaves

Chemically, it’s an ester of caffeic and quinic acid, functioning as a key antioxidant with clinically studied metabolic benefits.

Top 5 Science-Backed Benefits & Mechanisms

1. Metabolic Health & Weight Management
   • Boosts fat metabolism by modulating glucose-6-phosphatase (reduces liver glucose output)
   • Lowers blood sugar spikes post-meal (Diabetes Care, 2019)
2. Antioxidant Powerhouse
   • Neutralizes free radicals 2x more effectively than green tea EGCG (Journal of Agricultural Food Chemistry)
3. Cardiovascular Support
   • Reduces LDL oxidation and improves endothelial function (Hypertension Research, 2020)
4. Neuroprotection
   • Crosses blood-brain barrier; reduces neuroinflammation markers
5. Antimicrobial Activity
   • Effective against H. pylori, Candida, and oral pathogens Chlorogenic Acid Applications

Chlorogenic Acid vs. Green Coffee Extract

Dosing Protocol & Optimal Daily Intake

For End Products (Capsules/Tablets):

• Standard Dose: 120–300 mg/day (split into 2 doses)
• Weight Management: 200–400 mg/day pre-meals
• Functional Foods: 50–100 mg/serving (bars, shakes)

B2B Formulation Guidance:

1.  Solubility: Use microencapsulated CGA for beverages (oil-soluble base)  
2.  Stability: Pair with antioxidants (e.g., rosemary extract) to prevent degradation  
3.  Synergies: Combine with chromium for glucose control  

Best Practice: Start with 100 mg doses → clinically effective with minimal side effects.

Safety & Side Effects

• Generally Safe: EFSA/WHO-approved (ADI: ~5 mg/kg body weight)
• Rare Side Effects:
  • Mild digestive upset (doses >400 mg)
  • Jitteriness (when combined with caffeine)
• Contraindications:
  • Pregnancy (limited data)
  • Autoimmune disorders (theoretical immune modulation risk)