Chlorogenic Acid: Bulk Buyers Guide to Benefits, Dosing Sourcing Premium Extracts

16 Июль 2025, 00:45

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What is Chlorogenic Acid?

Chlorogenic Acid (CGA) is a potent polyphenol abundantly found in:

Green coffee beans (primary source)
Artichokes, strawberries, apples
Eucommia ulmoides leaves

Chemically, it’s an ester of caffeic and quinic acid, functioning as a key antioxidant with clinically studied metabolic benefits.

Top 5 Science-Backed Benefits & Mechanisms

Metabolic Health & Weight Management
- Boosts fat metabolism by modulating glucose-6-phosphatase (reduces liver glucose output)
- Lowers blood sugar spikes post-meal (Diabetes Care, 2019)
Antioxidant Powerhouse
- Neutralizes free radicals 2x more effectively than green tea EGCG (Journal of Agricultural Food Chemistry)
Cardiovascular Support
- Reduces LDL oxidation and improves endothelial function (Hypertension Research, 2020)
Neuroprotection
- Crosses blood-brain barrier; reduces neuroinflammation markers
Antimicrobial Activity
- Effective against H. pylori, Candida, and oral pathogens Chlorogenic Acid Applications

Chlorogenic Acid vs. Green Coffee Extract

Factor	Chlorogenic Acid (Purified)	Green Coffee Extract
CGA Concentration	20%-50%+ (Standardized)	5%-20% (Variable)
Consistency	Batch-to-batch reliability	Fluctuates with crop
Applications	Pharma, supplements, functional foods	Basic supplements

Dosing Protocol & Optimal Daily Intake

For End Products (Capsules/Tablets):

Standard Dose: 120–300 mg/day (split into 2 doses)
Weight Management: 200–400 mg/day pre-meals
Functional Foods: 50–100 mg/serving (bars, shakes)

B2B Formulation Guidance:

1.  Solubility: Use microencapsulated CGA for beverages (oil-soluble base)  
2.  Stability: Pair with antioxidants (e.g., rosemary extract) to prevent degradation  
3.  Synergies: Combine with chromium for glucose control

Best Practice: Start with 100 mg doses → clinically effective with minimal side effects.

Safety & Side Effects

Generally Safe: EFSA/WHO-approved (ADI: ~5 mg/kg body weight)
Rare Side Effects:
- Mild digestive upset (doses >400 mg)
- Jitteriness (when combined with caffeine)
Contraindications:
- Pregnancy (limited data)
- Autoimmune disorders (theoretical immune modulation risk)